Reaction Details |
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Target | Signal transducer and activator of transcription 1-alpha/beta |
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Ligand | BDBM43547 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation |
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EC50 | >55700±n/a nM |
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Citation | PubChem, PC Dose response counterscreen assay for STAT3 activators: cell-based high throughput assay to measure STAT1 activation PubChem Bioassay(2008)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Signal transducer and activator of transcription 1-alpha/beta |
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Name: | Signal transducer and activator of transcription 1-alpha/beta |
Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
Type: | Cytosolic Transcription Factor |
Mol. Mass.: | 87327.69 |
Organism: | Homo sapiens (Human) |
Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
Residue: | 750 |
Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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BDBM43547 |
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n/a |
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Name | BDBM43547 |
Synonyms: | (3-Cyano-2-methyl-indol-1-yl)-acetic acid | 2-(3-cyano-2-methyl-1-indolyl)acetic acid | 2-(3-cyano-2-methyl-indol-1-yl)acetic acid | 2-(3-cyano-2-methyl-indol-1-yl)ethanoic acid | 2-(3-cyano-2-methylindol-1-yl)acetic acid | MLS000075634 | SMR000013849 | cid_653215 |
Type | Small organic molecule |
Emp. Form. | C12H10N2O2 |
Mol. Mass. | 214.22 |
SMILES | Cc1c(C#N)c2ccccc2n1CC(O)=O |
Structure |
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