| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM39747 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay |
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| EC50 | 20900±n/a nM |
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| Citation |  PubChem, PC SAR assay for compounds activating TNAP in the absence of phosphate acceptor performed in a luminescent assay PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM39747 |
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| n/a |
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| Name | BDBM39747 |
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| Synonyms: | 1-benzyl-N'-[(1-ethyl-3,5-dimethyl-1H-pyrazol-4-yl)methylene]-2,3-dimethyl-1H-indole-5-carbohydrazide | 1-benzyl-N-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyleneamino]-2,3-dimethyl-indole-5-carboxamide | 1-benzyl-N-[(1-ethyl-3,5-dimethylpyrazol-4-yl)methylideneamino]-2,3-dimethylindole-5-carboxamide | 1-benzyl-N-[(E)-(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methyleneamino]-2,3-dimethyl-indole-5-carboxamide | MLS000537139 | N-[(1-ethyl-3,5-dimethyl-4-pyrazolyl)methylideneamino]-2,3-dimethyl-1-(phenylmethyl)-5-indolecarboxamide | N-[(1-ethyl-3,5-dimethyl-pyrazol-4-yl)methylideneamino]-2,3-dimethyl-1-(phenylmethyl)indole-5-carboxamide | SMR000159906 | cid_1227745 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H29N5O |
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| Mol. Mass. | 427.5414 |
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| SMILES | CCn1nc(C)c(C=NNC(=O)c2ccc3n(Cc4ccccc4)c(C)c(C)c3c2)c1C |w:8.8| |
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| Structure | 
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