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TargetMyristoyl-CoA:protein N-myristoyltransferase (Nmt)
LigandBDBM43854
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
IC50>1.40e+5± 0 nM
Citation Sogabe SMasubuchi MSakata KFukami TAMorikami KShiratori YEbiike HKawasaki KAoki YShimma ND'Arcy AWinkler FKBanner DWOhtsuka T Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol 9:1119-28 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)
Name:Peptide N-myristoyltransferase
Synonyms:N-myristoyltransferase (NMT1) | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:Enzyme
Mol. Mass.:56814.10
Organism:Homo sapiens (Human)
Description:P30419
Residue:496
Sequence:
MADESETAVKPPAPPLPQMMEGNGNGHEHCSDCENEEDNSYNRGGLSPANDTGAKKKKKK
QKKKKEKGSETDSAQDQPVKMNSLPAERIQEIQKAIELFSVGQGPAKTMEEASKRSYQFW
DTQPVPKLGEVVNTHGPVEPDKDNIRQEPYTLPQGFTWDALDLGDRGVLKELYTLLNENY
VEDDDNMFRFDYSPEFLLWALRPPGWLPQWHCGVRVVSSRKLVGFISAIPANIHIYDTEK
KMVEINFLCVHKKLRSKRVAPVLIREITRRVHLEGIFQAVYTAGVVLPKPVGTCRYWHRS
LNPRKLIEVKFSHLSRNMTMQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQF
HLTPVMSQEEVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNHPTHKSLKAAY
SFYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGDGNLQYYLYN
WKCPSMGAEKVGLVLQ
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  Blast E-value cutoff:
BDBM43854
n/a
NameBDBM43854
Synonyms:2-[(veratroylhydrazono)methyl]benzoic acid | 2-[[(3,4-dimethoxybenzoyl)hydrazinylidene]methyl]benzoic acid | 2-[[(3,4-dimethoxyphenyl)carbonylhydrazinylidene]methyl]benzoic acid | 2-[[[(3,4-dimethoxyphenyl)-oxomethyl]hydrazinylidene]methyl]benzoic acid | MLS000774113 | SC-58272 | SMR000365110 | cid_958176
TypeSmall organic molecule
Emp. Form.C17H16N2O5
Mol. Mass.328.3193
SMILESCOc1ccc(cc1OC)C(=O)NN=Cc1ccccc1C(O)=O |w:13.13|
Structure
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