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TargetMyristoyl-CoA:protein N-myristoyltransferase (Nmt)
LigandBDBM43854
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
Ki 6.5e+2± 0 nM
Citation Sogabe SMasubuchi MSakata KFukami TAMorikami KShiratori YEbiike HKawasaki KAoki YShimma ND'Arcy AWinkler FKBanner DWOhtsuka T Crystal structures of Candida albicans N-myristoyltransferase with two distinct inhibitors. Chem Biol 9:1119-28 (2002) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Myristoyl-CoA:protein N-myristoyltransferase (Nmt)
Name:Myristoyl-CoA:protein N-myristoyltransferase (Nmt)
Synonyms:Myristoyl-CoA:protein N-myristoyltransferase | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D110A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D112A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt D412A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F115A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F117A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F240A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt F339S)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt G413A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt H227A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I111A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt I352A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L350V)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt L451Q)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt N175A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt P229A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt S241A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T114A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt T211A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt V108A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt W232A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y107A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y119A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y225A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y256A)) | Myristoyl-CoA:protein N-myristoyltransferase (Nmt Y354A)) | NMT | Peptide N-myristoyltransferase | Peptide N-myristoyltransferase 1
Type:Enzyme
Mol. Mass.:51875.96
Organism:Candida albicans (Yeast)
Description:P30418
Residue:451
Sequence:
MSGDNTGNKSNSAPSKSIEELLKLLAMGQELSPAQQKEMKDYKFWKTQPVPSLSETVTEE
GPIDKLKTPEDVPNDPLPLISDFEWSTLDIDDNLQLDELYKLLYDNYVEDIDATFRFKYS
HEFFQWALKPPGWRKDWHVGVRVKSTGKLVAFIAATPVTFKLNKSNKVIDSVEINFLCIH
KKLRNKRLAPVLIKEITRRVNKQNIWQALYTGGSILPTPLTTCRYQHRPINWSKLHDVGF
SHLPPNQTKSSMVASYTLPNNPKLKGLRPMTGKDVSTVLSLLYKYQERFDIVQLFTEEEF
KHWMLGHDENSDSNVVKSYVVEDENGIITDYFSYYLLPFTVLDNAQHDELGIAYLFYYAS
DSFEKPNYKKRLNELITDALITSKKFGVDVFNCLTCQDNTYFLKDCKFGSGDGFLNYYLF
NYRTFPMDGGIDKKTKEVVEDQTSGIGVVLL
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BDBM43854
n/a
NameBDBM43854
Synonyms:2-[(veratroylhydrazono)methyl]benzoic acid | 2-[[(3,4-dimethoxybenzoyl)hydrazinylidene]methyl]benzoic acid | 2-[[(3,4-dimethoxyphenyl)carbonylhydrazinylidene]methyl]benzoic acid | 2-[[[(3,4-dimethoxyphenyl)-oxomethyl]hydrazinylidene]methyl]benzoic acid | MLS000774113 | SC-58272 | SMR000365110 | cid_958176
TypeSmall organic molecule
Emp. Form.C17H16N2O5
Mol. Mass.328.3193
SMILESCOc1ccc(cc1OC)C(=O)NN=Cc1ccccc1C(O)=O |w:13.13|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: