| Reaction Details |
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 | Report a problem with these data |
| Target | E3 ubiquitin-protein ligase XIAP |
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| Ligand | BDBM44280 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR analysis of Antagonists of IAP-family anti-apoptotic proteins |
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| IC50 | 17500±3500 nM |
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| Citation |  PubChem, PC SAR analysis of Antagonists of IAP-family anti-apoptotic proteins PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| E3 ubiquitin-protein ligase XIAP |
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| Name: | E3 ubiquitin-protein ligase XIAP |
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| Synonyms: | API3 | BIRC4 | E3 ubiquitin-protein ligase XIAP | IAP3 | Inhibitor of apoptosis protein 3 | Inhibitor of apoptosis protein 3 (XIAP) | X-linked inhibitor of apoptosis | X-linked inhibitor of apoptosis protein (XIAP) | XIAP | XIAP_HUMAN |
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| Type: | Protein |
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| Mol. Mass.: | 56685.27 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P98170 |
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| Residue: | 497 |
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| Sequence: | MTFNSFEGSKTCVPADINKEEEFVEEFNRLKTFANFPSGSPVSASTLARAGFLYTGEGDT
VRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFINGFYLENSATQSTNSGIQNGQYKVENY
LGSRDHFALDRPSETHADYLLRTGQVVDISDTIYPRNPAMYSEEARLKSFQNWPDYAHLT
PRELASAGLYYTGIGDQVQCFCCGGKLKNWEPCDRAWSEHRRHFPNCFFVLGRNLNIRSE
SDAVSSDRNFPNSTNLPRNPSMADYEARIFTFGTWIYSVNKEQLARAGFYALGEGDKVKC
FHCGGGLTDWKPSEDPWEQHAKWYPGCKYLLEQKGQEYINNIHLTHSLEECLVRTTEKTP
SLTRRIDDTIFQNPMVQEAIRMGFSFKDIKKIMEEKIQISGSNYKSLEVLVADLVNAQKD
SMQDESSQTSLQKEISTEEQLRRLQEEKLCKICMDRNIAIVFVPCGHLVTCKQCAEAVDK
CPMCYTVITFKQKIFMS
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| BDBM44280 |
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| n/a |
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| Name | BDBM44280 |
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| Synonyms: | (2S)-1-[(2S)-2-[[(2S)-2-amino-1-oxopropyl]amino]-2-cyclohexyl-1-oxoethyl]-2-pyrrolidinecarboxylic acid (phenylmethyl) ester;2,2,2-trifluoroacetic acid | (2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-2-cyclohexyl-acetyl]pyrrolidine-2-carboxylic acid benzyl ester;2,2,2-trifluoroacetic acid | (phenylmethyl) (2S)-1-[(2S)-2-[[(2S)-2-azanylpropanoyl]amino]-2-cyclohexyl-ethanoyl]pyrrolidine-2-carboxylate;2,2,2-tris(fluoranyl)ethanoic acid | MLS-0390978.0001 | benzyl (2S)-1-[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-2-cyclohexylacetyl]pyrrolidine-2-carboxylate;2,2,2-trifluoroacetic acid | cid_25241685 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H33N3O4 |
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| Mol. Mass. | 415.5258 |
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| SMILES | C[C@H](N)C(=O)N[C@@H](C1CCCCC1)C(=O)N1CCC[C@H]1C(=O)OCc1ccccc1 |
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| Structure | 
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