| Reaction Details |
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 | Report a problem with these data |
| Target | Ephrin type-A receptor 4 |
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| Ligand | BDBM44480 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists |
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| IC50 | 9900±n/a nM |
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| Citation |  PubChem, PC Colorimetric assay for HTS discovery of chemical inhibitors of EphA4 receptor antagonists PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Ephrin type-A receptor 4 |
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| Name: | Ephrin type-A receptor 4 |
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| Synonyms: | EPHA4_MOUSE | Eph receptor A4 | Epha4 | Sek | Sek1 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 109812.17 |
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| Organism: | Mus musculus |
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| Description: | gi_34328113 |
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| Residue: | 986 |
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| Sequence: | MAGIFYFILFSFLFGICDAVTGSRVYPANEVTLLDSRSVQGELGWIASPLEGGWEEVSIM
DEKNTPIRTYQVCNVMEASQNNWLRTDWITREGAQRVYIEIKFTLRDCNSLPGVMGTCKE
TFNLYYYESDNDKERFIRESQFGKIDTIAADESFTQVDIGDRIMKLNTEIRDVGPLSKKG
FYLAFQDVGACIALVSVRVFYKKCPLTVRNLAQFPDTITGADTSSLVEVRGSCVNNSEEK
DVPKMYCGADGEWLVPIGNCLCNAGHEEQNGECQACKIGYYKALSTDASCAKCPPHSYSV
WEGATSCTCDRGFFRADNDAASMPCTRPPSAPLNLISNVNETSVNLEWSSPQNTGGRQDI
SYNVVCKKCGAGDPSKCRPCGSGVHYTPQQNGLKTTRVSITDLLAHTNYTFEIWAVNGVS
KYNPSPDQSVSVTVTTNQAAPSSIALVQAKEVTRYSVALAWLEPDRPNGVILEYEVKYYE
KDQNERSYRIVRTAARNTDIKGLNPLTSYVFHVRARTAAGYGDFSEPLEVTTNTVPSRII
GDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVRTYVDPF
TYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRLKVPGKREICVAIKTLKAGYT
DKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFLRKNDGRFTV
IQLVGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSNLVCKVSDFGMSRVLEDDPEAAYT
TRGGKIPIRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIKAIEEG
YRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVNMLDKLIRNPNSLKRTGSESSRPNT
ALLDPSSPEFSAVVSVGDWLQAIKMDRYKDNFTAAGYTTLEAVVHMSQDDLARIGITAIT
HQNKILSSVQAMRTQMQQMHGRMVPV
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| BDBM44480 |
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| n/a |
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| Name | BDBM44480 |
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| Synonyms: | 1-(3-Amino-6-thiophen-2-yl-4-trifluoromethyl-thieno[2,3-b]pyridin-2-yl)-2,2-dimethyl-propan-1-one | 1-[3-amino-6-(2-thienyl)-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]-2,2-dimethyl-propan-1-one | 1-[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)-2-thieno[2,3-b]pyridinyl]-2,2-dimethyl-1-propanone | 1-[3-amino-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]-2,2-dimethylpropan-1-one | 1-[3-azanyl-6-thiophen-2-yl-4-(trifluoromethyl)thieno[2,3-b]pyridin-2-yl]-2,2-dimethyl-propan-1-one | MLS000558164 | SMR000148880 | cid_1272770 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H15F3N2OS2 |
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| Mol. Mass. | 384.439 |
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| SMILES | CC(C)(C)C(=O)c1sc2nc(cc(c2c1N)C(F)(F)F)-c1cccs1 |
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| Structure | 
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