| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM41755 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. |
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| EC50 | >50000±n/a nM |
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| Citation |  PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay(2007)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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| BDBM41755 |
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| n/a |
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| Name | BDBM41755 |
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| Synonyms: | 3-[(1-Cyclopentyl-1H-tetrazol-5-yl)-(4-phenyl-piperazin-1-yl)-methyl]-7-methyl-1H-quinolin-2-one | 3-[(1-cyclopentyl-1,2,3,4-tetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one | 3-[(1-cyclopentyl-5-tetrazolyl)-(4-phenyl-1-piperazinyl)methyl]-7-methyl-1H-quinolin-2-one | 3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazin-1-yl)methyl]-7-methyl-1H-quinolin-2-one | 3-[(1-cyclopentyltetrazol-5-yl)-(4-phenylpiperazino)methyl]-7-methyl-carbostyril | MLS000071942 | SMR000002493 | cid_650853 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H31N7O |
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| Mol. Mass. | 469.5813 |
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| SMILES | Cc1ccc2cc(C(N3CCN(CC3)c3ccccc3)c3nnnn3C3CCCC3)c(=O)[nH]c2c1 |
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| Structure | 
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