| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
|---|
| Ligand | BDBM41776 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. |
|---|
| EC50 | >50000±n/a nM |
|---|
| Citation |  PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay(2007)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Serine/threonine-protein kinase PLK1 |
|---|
| Name: | Serine/threonine-protein kinase PLK1 |
|---|
| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
|---|
| Type: | Serine/threonine-protein kinase |
|---|
| Mol. Mass.: | 68277.16 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P53350 |
|---|
| Residue: | 603 |
|---|
| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
|
|
|
|---|
| BDBM41776 |
|---|
| n/a |
|---|
| Name | BDBM41776 |
|---|
| Synonyms: | 3-ethyl-6-[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl-5-methyl-thieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methyl-thieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[4-(4-methoxyphenyl)piperazine-1-carbonyl]-5-methylthieno[2,3-d]pyrimidin-4-one | 3-ethyl-6-[[4-(4-methoxyphenyl)-1-piperazinyl]-oxomethyl]-5-methyl-4-thieno[2,3-d]pyrimidinone | 3-ethyl-6-{[4-(4-methoxyphenyl)piperazin-1-yl]carbonyl}-5-methylthieno[2,3-d]pyrimidin-4(3H)-one | MLS000089815 | SMR000024433 | cid_3241114 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H24N4O3S |
|---|
| Mol. Mass. | 412.505 |
|---|
| SMILES | CCn1cnc2sc(C(=O)N3CCN(CC3)c3ccc(OC)cc3)c(C)c2c1=O |
|---|
| Structure | 
|
|---|
Search and Browse
