| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase PLK1 |
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| Ligand | BDBM41819 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. |
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| EC50 | >50000±n/a nM |
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| Citation |  PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay(2007)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Serine/threonine-protein kinase PLK1 |
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| Name: | Serine/threonine-protein kinase PLK1 |
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| Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
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| Type: | Serine/threonine-protein kinase |
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| Mol. Mass.: | 68277.16 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P53350 |
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| Residue: | 603 |
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| Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
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|
|
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| BDBM41819 |
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| n/a |
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| Name | BDBM41819 |
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| Synonyms: | 3-(isopropylthio)-6,6,7-trimethyl-1-morpholino-5,8-dihydro-2,7-naphthyridine-4-carbonitrile | 3-Isopropylsulfanyl-6,6,7-trimethyl-1-morpholin-4-yl-5,6,7,8-tetrahydro-[2,7]naphthyridine-4-carbonitrile | 6,6,7-trimethyl-1-(4-morpholinyl)-3-(propan-2-ylthio)-5,8-dihydro-2,7-naphthyridine-4-carbonitrile | 6,6,7-trimethyl-1-morpholin-4-yl-3-propan-2-ylsulfanyl-5,8-dihydro-2,7-naphthyridine-4-carbonitrile | MLS000552515 | SMR000146030 | cid_3790338 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H28N4OS |
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| Mol. Mass. | 360.517 |
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| SMILES | CC(C)Sc1nc(N2CCOCC2)c2CN(C)C(C)(C)Cc2c1C#N |
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| Structure | 
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