Reaction Details |
| Report a problem with these data |
Target | Serine/threonine-protein kinase PLK1 |
---|
Ligand | BDBM41835 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. |
---|
EC50 | >50000±n/a nM |
---|
Citation | PubChem, PC Concentration Response Redox Cycling H2O2 Generation assay, 1 mM DTT, to characterize small molecule inhibitors identified in the Polo box domain (PBD) of Plk1 Primary HTS. PubChem Bioassay(2007)[AID] |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Serine/threonine-protein kinase PLK1 |
---|
Name: | Serine/threonine-protein kinase PLK1 |
Synonyms: | PLK | PLK-1 | PLK1 | PLK1_HUMAN | Polo-like kinase 1 (PlK1) | Polo-like kinase 1 (Plk-1) | STPK13 | Serine/threonine-protein kinase (PLK1) | Serine/threonine-protein kinase 13 | polo-like kinase |
Type: | Serine/threonine-protein kinase |
Mol. Mass.: | 68277.16 |
Organism: | Homo sapiens (Human) |
Description: | P53350 |
Residue: | 603 |
Sequence: | MSAAVTAGKLARAPADPGKAGVPGVAAPGAPAAAPPAKEIPEVLVDPRSRRRYVRGRFLG
KGGFAKCFEISDADTKEVFAGKIVPKSLLLKPHQREKMSMEISIHRSLAHQHVVGFHGFF
EDNDFVFVVLELCRRRSLLELHKRRKALTEPEARYYLRQIVLGCQYLHRNRVIHRDLKLG
NLFLNEDLEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLSKKGHSFEVDVWSIGCI
MYTLLVGKPPFETSCLKETYLRIKKNEYSIPKHINPVAASLIQKMLQTDPTARPTINELL
NDEFFTSGYIPARLPITCLTIPPRFSIAPSSLDPSNRKPLTVLNKGLENPLPERPREKEE
PVVRETGEVVDCHLSDMLQQLHSVNASKPSERGLVRQEEAEDPACIPIFWVSKWVDYSDK
YGLGYQLCDNSVGVLFNDSTRLILYNDGDSLQYIERDGTESYLTVSSHPNSLMKKITLLK
YFRNYMSEHLLKAGANITPREGDELARLPYLRTWFRTRSAIILHLSNGSVQINFFQDHTK
LILCPLMAAVTYIDEKRDFRTYRLSLLEEYGCCKELASRLRYARTMVDKLLSSRSASNRL
KAS
|
|
|
BDBM41835 |
---|
n/a |
---|
Name | BDBM41835 |
Synonyms: | 6-amino-1-benzyl-3-methyl-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]acetyl]pyrimidine-2,4-dione | 6-amino-1-benzyl-5-[2-[[5-(isopropylamino)-1,3,4-thiadiazol-2-yl]thio]acetyl]-3-methyl-pyrimidine-2,4-quinone | 6-amino-3-methyl-5-[1-oxo-2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]thio]ethyl]-1-(phenylmethyl)pyrimidine-2,4-dione | 6-azanyl-3-methyl-1-(phenylmethyl)-5-[2-[[5-(propan-2-ylamino)-1,3,4-thiadiazol-2-yl]sulfanyl]ethanoyl]pyrimidine-2,4-dione | MLS000568091 | SMR000154422 | cid_2501656 |
Type | Small organic molecule |
Emp. Form. | C19H22N6O3S2 |
Mol. Mass. | 446.546 |
SMILES | CC(C)Nc1nnc(SCC(=O)c2c(N)n(Cc3ccccc3)c(=O)n(C)c2=O)s1 |
Structure |
|