| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Ligand | BDBM36974 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition |
|---|
| IC50 | >55700±n/a nM |
|---|
| Citation |  PubChem, PC Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition PubChem Bioassay(2008)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Name: | Signal transducer and activator of transcription 1-alpha/beta |
|---|
| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
|---|
| Type: | Cytosolic Transcription Factor |
|---|
| Mol. Mass.: | 87327.69 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
|---|
| Residue: | 750 |
|---|
| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
|
|
|
|---|
| BDBM36974 |
|---|
| n/a |
|---|
| Name | BDBM36974 |
|---|
| Synonyms: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methylsulfanyl]-1-[4-(2,3-dimethylphenyl)piperazin-1-yl]ethanone | 2-[(3,5-dimethyl-4-isoxazolyl)methylthio]-1-[4-(2,3-dimethylphenyl)-1-piperazinyl]ethanone | 2-[(3,5-dimethylisoxazol-4-yl)methylthio]-1-[4-(2,3-dimethylphenyl)piperazino]ethanone | MLS000053719 | SMR000064422 | US10544110, Compound 1 | cid_2537506 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H27N3O2S |
|---|
| Mol. Mass. | 373.512 |
|---|
| SMILES | Cc1noc(C)c1CSCC(=O)N1CCN(CC1)c1cccc(C)c1C |
|---|
| Structure | 
|
|---|
Search and Browse
