| Reaction Details |
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 | Report a problem with these data |
| Target | Signal transducer and activator of transcription 1-alpha/beta |
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| Ligand | BDBM40249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition |
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| IC50 | 16120±n/a nM |
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| Citation |  PubChem, PC Dose response counterscreen assay for STAT3 inhibitors: cell-based high throughput assay to measure STAT1 inhibition PubChem Bioassay(2008)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Signal transducer and activator of transcription 1-alpha/beta |
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| Name: | Signal transducer and activator of transcription 1-alpha/beta |
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| Synonyms: | STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha |
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| Type: | Cytosolic Transcription Factor |
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| Mol. Mass.: | 87327.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA. |
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| Residue: | 750 |
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| Sequence: | MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDL
LSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQ
RFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNR
EHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWK
RRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQV
LWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKV
KVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTN
EGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAE
PRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWT
RFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFL
LRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIP
ENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTT
DNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
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| BDBM40249 |
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| n/a |
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| Name | BDBM40249 |
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| Synonyms: | 5-(1,3-benzothiazol-2-yl)-N-propyl-2-thiophenecarboxamide | 5-(1,3-benzothiazol-2-yl)-N-propyl-thiophene-2-carboxamide | 5-(1,3-benzothiazol-2-yl)-N-propylthiophene-2-carboxamide | MLS000566279 | SMR000153391 | cid_2452036 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H14N2OS2 |
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| Mol. Mass. | 302.414 |
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| SMILES | CCCNC(=O)c1ccc(s1)-c1nc2ccccc2s1 |
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| Structure | 
|
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