| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 3 |
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| Ligand | BDBM46448 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Dose response cell-based high-throughput screening assay to measure PERK inhibition |
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| EC50 | >55700±n/a nM |
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| Citation |  PubChem, PC Dose response cell-based high-throughput screening assay to measure PERK inhibition PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Eukaryotic translation initiation factor 2-alpha kinase 3 |
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| Name: | Eukaryotic translation initiation factor 2-alpha kinase 3 |
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| Synonyms: | E2AK3_HUMAN | EIF2AK3 | HsPEK | PEK | PERK | Pancreatic eIF2-alpha kinase | Pancreatic endoplasmic reticulum kinase (PERK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 125190.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q9NZJ5 |
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| Residue: | 1116 |
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| Sequence: | MERAISPGLLVRALLLLLLLLGLAARTVAAGRARGLPAPTAEAAFGLGAAAAPTSATRVP
AAGAVAAAEVTVEDAEALPAAAGEQEPRGPEPDDETELRPRGRSLVIISTLDGRIAALDP
ENHGKKQWDLDVGSGSLVSSSLSKPEVFGNKMIIPSLDGALFQWDQDRESMETVPFTVES
LLESSYKFGDDVVLVGGKSLTTYGLSAYSGKVRYICSALGCRQWDSDEMEQEEDILLLQR
TQKTVRAVGPRSGNEKWNFSVGHFELRYIPDMETRAGFIESTFKPNENTEESKIISDVEE
QEAAIMDIVIKVSVADWKVMAFSKKGGHLEWEYQFCTPIASAWLLKDGKVIPISLFDDTS
YTSNDDVLEDEEDIVEAARGATENSVYLGMYRGQLYLQSSVRISEKFPSSPKALESVTNE
NAIIPLPTIKWKPLIHSPSRTPVLVGSDEFDKCLSNDKFSHEEYSNGALSILQYPYDNGY
YLPYYKRERNKRSTQITVRFLDNPHYNKNIRKKDPVLLLHWWKEIVATILFCIIATTFIV
RRLFHPHPHRQRKESETQCQTENKYDSVSGEANDSSWNDIKNSGYISRYLTDFEPIQCLG
RGGFGVVFEAKNKVDDCNYAIKRIRLPNRELAREKVMREVKALAKLEHPGIVRYFNAWLE
APPEKWQEKMDEIWLKDESTDWPLSSPSPMDAPSVKIRRMDPFATKEHIEIIAPSPQRSR
SFSVGISCDQTSSSESQFSPLEFSGMDHEDISESVDAAYNLQDSCLTDCDVEDGTMDGND
EGHSFELCPSEASPYVRSRERTSSSIVFEDSGCDNASSKEEPKTNRLHIGNHCANKLTAF
KPTSSKSSSEATLSISPPRPTTLSLDLTKNTTEKLQPSSPKVYLYIQMQLCRKENLKDWM
NGRCTIEERERSVCLHIFLQIAEAVEFLHSKGLMHRDLKPSNIFFTMDDVVKVGDFGLVT
AMDQDEEEQTVLTPMPAYARHTGQVGTKLYMSPEQIHGNSYSHKVDIFSLGLILFELLYP
FSTQMERVRTLTDVRNLKFPPLFTQKYPCEYVMVQDMLSPSPMERPEAINIIENAVFEDL
DFPGKTVLRQRSRSLSSSGTKHSRQSNNSHSPLPSN
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| BDBM46448 |
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| n/a |
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| Name | BDBM46448 |
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| Synonyms: | 2-[(4-methylphenyl)amino]-2-oxoethyl 3-(2-oxo-2,3-dihydro-1H-imidazol-4-yl)propanoate | 3-(2-keto-4-imidazolin-4-yl)propionic acid [2-keto-2-(p-toluidino)ethyl] ester | 3-(2-oxo-1,3-dihydroimidazol-4-yl)propanoic acid [2-(4-methylanilino)-2-oxoethyl] ester | MLS000088042 | SMR000072249 | [2-(4-methylanilino)-2-oxoethyl] 3-(2-oxo-1,3-dihydroimidazol-4-yl)propanoate | [2-[(4-methylphenyl)amino]-2-oxidanylidene-ethyl] 3-(2-oxidanylidene-1,3-dihydroimidazol-4-yl)propanoate | cid_753474 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H17N3O4 |
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| Mol. Mass. | 303.3132 |
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| SMILES | Cc1ccc(NC(=O)COC(=O)CCc2c[nH]c(=O)[nH]2)cc1 |
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| Structure | 
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