| Reaction Details |
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 | Report a problem with these data |
| Target | Gag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C] |
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| Ligand | BDBM2042 |
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| Substrate/Competitor | poly(rC)500:oligo(dG)10 |
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| Meas. Tech. | HIV-1 RT Assay |
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| pH | 7.8±n/a |
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| Temperature | 295.15±n/a K |
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| IC50 | 90±n/a nM |
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| Citation |  Cywin, CL; Sarver, RW; Klunder, JM; Bills, E; Hoermann, M; Bolton, G; Bratton, LD; Brickwood, JR; Caspers, NL; David, E; Dunbar, JB; Grob, PM; Schwartz, R; Harris, MS; Pauletti, D; Hutchings, RH; Barringer, KJ; Kennedy, RM; Shih, CK; Larsen, SD; Pavlovsky, A; Sorge, CL; Erickson, DA; Pfefferkorn, JA; Joseph, DP; Bainbridge, G; Hattox, SE Thermodynamic and structure guided design of statin based inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase. J Med Chem51:3804-13 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| |
| Gag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C] |
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| Name: | Gag-Pol polyprotein [600-1027,Y780C]/[600-1155,Y780C] |
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| Synonyms: | EC: 2.7.7.49 | HIV-1 Reverse Transcriptase Mutant (Y181C) |
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| Type: | Protein Complex |
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| Mol. Mass.: | 115564 |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Gag-Pol polyprotein [600-1155,Y780C] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain A | POL_HV1B1 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 63868.77 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03366[600-1155,Y780C] |
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| Residue: | 556 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNKGRQKVVPLTNTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDKSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGI
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| Component 2 |
| Name: | Gag-Pol polyprotein [600-1027,Y780C] |
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| Synonyms: | HIV-1 Reverse Transcriptase Mutant (Y181C) Chain B | POL_HV1B1 | gag-pol |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 49908.60 |
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| Organism: | Human immunodeficiency virus type 1 |
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| Description: | P03366[600-1027,Y780C] |
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| Residue: | 428 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKKKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFKKQNPDIVI
CQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIKVKQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLKTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQ
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| BDBM2042 |
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| poly(rC)500:oligo(dG)10 |
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| Name: | poly(rC)500:oligo(dG)10 |
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| Synonyms: | n/a |
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| Type: | RNA\DNA duplex |
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| Mol. Mass.: | 358.43 |
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| Organism: | n/a |
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| Description: | The incorporation of Tritium-labeled dGTP onto a (poly)rC:(oligo)dG template:primer. |
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| Residue: | 3 |
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| Sequence: | |
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