| Reaction Details |
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 | Report a problem with these data |
| Target | Protein-tyrosine kinase 2-beta |
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| Ligand | BDBM41084 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) |
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| IC50 | 4500±n/a nM |
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| Citation |  PubChem, PC TR-FRET counterscreen for FAK inhibitors: dose-response biochemical high throughput screening assay to identify inhibitors of Proline-rich tyrosine kinase 2 (Pyk2) PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Protein-tyrosine kinase 2-beta |
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| Name: | Protein-tyrosine kinase 2-beta |
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| Synonyms: | FAK2 | FAK2_HUMAN | PTK2B | PTK2B protein tyrosine kinase 2 beta | PTK2B protein tyrosine kinase 2 beta (PTK2B) | PYK2 | Protein tyrosine kinase 2 beta | RAFTK |
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| Type: | Protein |
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| Mol. Mass.: | 115868.80 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14289 |
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| Residue: | 1009 |
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| Sequence: | MSGVSEPLSRVKLGTLRRPEGPAEPMVVVPVDVEKEDVRILKVCFYSNSFNPGKNFKLVK
CTVQTEIREIITSILLSGRIGPNIRLAECYGLRLKHMKSDEIHWLHPQMTVGEVQDKYEC
LHVEAEWRYDLQIRYLPEDFMESLKEDRTTLLYFYQQLRNDYMQRYASKVSEGMALQLGC
LELRRFFKDMPHNALDKKSNFELLEKEVGLDLFFPKQMQENLKPKQFRKMIQQTFQQYAS
LREEECVMKFFNTLAGFANIDQETYRCELIQGWNITVDLVIGPKGIRQLTSQDAKPTCLA
EFKQIRSIRCLPLEEGQAVLQLGIEGAPQALSIKTSSLAEAENMADLIDGYCRLQGEHQG
SLIIHPRKDGEKRNSLPQIPMLNLEARRSHLSESCSIESDIYAEIPDETLRRPGGPQYGI
AREDVVLNRILGEGFFGEVYEGVYTNHKGEKINVAVKTCKKDCTLDNKEKFMSEAVIMKN
LDHPHIVKLIGIIEEEPTWIIMELYPYGELGHYLERNKNSLKVLTLVLYSLQICKAMAYL
ESINCVHRDIAVRNILVASPECVKLGDFGLSRYIEDEDYYKASVTRLPIKWMSPESINFR
RFTTASDVWMFAVCMWEILSFGKQPFFWLENKDVIGVLEKGDRLPKPDLCPPVLYTLMTR
CWDYDPSDRPRFTELVCSLSDVYQMEKDIAMEQERNARYRTPKILEPTAFQEPPPKPSRP
KYRPPPQTNLLAPKLQFQVPEGLCASSPTLTSPMEYPSPVNSLHTPPLHRHNVFKRHSMR
EEDFIQPSSREEAQQLWEAEKVKMRQILDKQQKQMVEDYQWLRQEEKSLDPMVYMNDKSP
LTPEKEVGYLEFTGPPQKPPRLGAQSIQPTANLDRTDDLVYLNVMELVRAVLELKNELCQ
LPPEGYVVVVKNVGLTLRKLIGSVDDLLPSLPSSSRTEIEGTQKLLNKDLAELINKMRLA
QQNAVTSLSEECKRQMLTASHTLAVDAKNLLDAVDQAKVLANLAHPPAE
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| BDBM41084 |
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| n/a |
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| Name | BDBM41084 |
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| Synonyms: | MLS000571311 | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-keto-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxidanylidene-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxo-2H-chromene-3-carboxamide | N-(3-imidazo[1,2-a]pyridin-2-ylphenyl)-2-oxochromene-3-carboxamide | N-[3-(2-imidazo[1,2-a]pyridinyl)phenyl]-2-oxo-1-benzopyran-3-carboxamide | SMR000193680 | cid_2877674 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15N3O3 |
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| Mol. Mass. | 381.3835 |
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| SMILES | O=C(Nc1cccc(c1)-c1cn2ccccc2n1)c1cc2ccccc2oc1=O |
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| Structure | 
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