Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 7

Ligand

BDBM47721

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao.

EC50

>30000±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS7-Galphao. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 7

Name:

Regulator of G-protein signaling 7

Synonyms:

RGS7 | RGS7_HUMAN

Type:

Enzyme Catalytic Domain

Mol. Mass.:

57675.72

Organism:

Homo sapiens (Human)

Description:

P49802

Residue:

495

Sequence:

MAQGNNYGQTSNGVADESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGS
DIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNC
WEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKK
RDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSH
SPTHTPTPETKPPTEDELQQQIKYWQIQLDRHRLKMSKVADSLLSYTEQYLEYDPFLLPP
DPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENL
RFWLAVEDLKKRPIKEVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFE
DAQEHIYKLMKSDSYPRFIRSSAYQELLQAKKKSGNSMDRRTSFEKFAQNVGRNIPIFPC
HKNCTPTLRASTNLL

BDBM47721

n/a

Name

BDBM47721

Synonyms:

MLS000523066 | N-[2-[6-[4-(2,5-dimethylphenyl)piperazin-1-yl]carbonyl-3-oxidanylidene-4H-quinoxalin-2-yl]phenyl]ethanamide | N-[2-[6-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3-keto-4H-quinoxalin-2-yl]phenyl]acetamide | N-[2-[6-[4-(2,5-dimethylphenyl)piperazine-1-carbonyl]-3-oxo-4H-quinoxalin-2-yl]phenyl]acetamide | N-[2-[6-[[4-(2,5-dimethylphenyl)-1-piperazinyl]-oxomethyl]-3-oxo-4H-quinoxalin-2-yl]phenyl]acetamide | SMR000128332 | cid_9551426

Type

Small organic molecule

Emp. Form.

C29H29N5O3

Mol. Mass.

495.5723

SMILES

CC(=O)Nc1ccccc1-c1nc2ccc(cc2[nH]c1=O)C(=O)N1CCN(CC1)c1cc(C)ccc1C

Structure