Ki Summary

Reaction Details

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Target

Regulator of G-protein signaling 19

Ligand

BDBM34510

Substrate/Competitor

n/a

Meas. Tech.

Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS19-Galphao.

EC50

2240±n/a nM

Citation

PubChem, PC Dose response, multiplexed high-throughput screen for small molecule regulators of RGS family protein interactions, specifically RGS19-Galphao. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Regulator of G-protein signaling 19

Name:

Regulator of G-protein signaling 19

Synonyms:

Type:

Enzyme Catalytic Domain

Mol. Mass.:

24631.38

Organism:

Homo sapiens (Human)

Description:

gi_86990435

Residue:

217

Sequence:

MPTPHEAEKQITGPEEADRPPSMSSHDTASPAAPSRNPCCLCWCCCCSCSWNQERRRAWQ
ASRESKLQPLPSCEVCATPSPEEVQSWAQSFDKLMHSPAGRSVFRAFLRTEYSEENMLFW
LACEELKAEANQHVVDEKARLIYEDYVSILSPKEVSLDSRVREGINKKMQEPSAHTFDDA
QLQIYTLMHRDSYPRFLSSPTYRALLLQGPSQSSSEA

BDBM34510

n/a

Name

BDBM34510

Synonyms:

1-[2-(3-keto-4,6-dimethyl-isothiazolo[5,4-b]pyridin-2-yl)acetyl]nipecotic acid ethyl ester | 1-[2-(4,6-dimethyl-3-oxo-2-isothiazolo[5,4-b]pyridinyl)-1-oxoethyl]-3-piperidinecarboxylic acid ethyl ester | MLS000118886 | SMR000095826 | cid_5308606 | ethyl 1-[2-(4,6-dimethyl-3-oxidanylidene-[1,2]thiazolo[5,4-b]pyridin-2-yl)ethanoyl]piperidine-3-carboxylate | ethyl 1-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperidine-3-carboxylate

Type

Small organic molecule

Emp. Form.

C18H23N3O4S

Mol. Mass.

377.458

SMILES

CCOC(=O)C1CCCN(C1)C(=O)Cn1sc2nc(C)cc(C)c2c1=O

Structure