| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 4 gamma 1 |
|---|
| Ligand | BDBM40324 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation |
|---|
| IC50 | 10825.14398±n/a nM |
|---|
| Citation |  PubChem, PC Dose Response Confirmation for Small Molecule Inhibitors of Eukaryotic Translation Initiation PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Eukaryotic translation initiation factor 4 gamma 1 |
|---|
| Name: | Eukaryotic translation initiation factor 4 gamma 1 |
|---|
| Synonyms: | EIF4F | EIF4G | EIF4G1 | EIF4GI | IF4G1_HUMAN | eukaryotic translation initiation factor 4 gamma, 1 isoform 4 |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 175455.17 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q04637 |
|---|
| Residue: | 1599 |
|---|
| Sequence: | MNKAPQSTGPPPAPSPGLPQPAFPPGQTAPVVFSTPQATQMNTPSQPRQHFYPSRAQPPS
SAASRVQSAAPARPGPAAHVYPAGSQVMMIPSQISYPASQGAYYIPGQGRSTYVVPTQQY
PVQPGAPGFYPGASPTEFGTYAGAYYPAQGVQQFPTGVAPTPVLMNQPPQIAPKRERKTI
RIRDPNQGGKDITEEIMSGARTASTPTPPQTGGGLEPQANGETPQVAVIVRPDDRSQGAI
IADRPGLPGPEHSPSESQPSSPSPTPSPSPVLEPGSEPNLAVLSIPGDTMTTIQMSVEES
TPISRETGEPYRLSPEPTPLAEPILEVEVTLSKPVPESEFSSSPLQAPTPLASHTVEIHE
PNGMVPSEDLEPEVESSPELAPPPACPSESPVPIAPTAQPEELLNGAPSPPAVDLSPVSE
PEEQAKEVTASMAPPTIPSATPATAPSATSPAQEEEMEEEEEEEEGEAGEAGEAESEKGG
EELLPPESTPIPANLSQNLEAAAATQVAVSVPKRRRKIKELNKKEAVGDLLDAFKEANPA
VPEVENQPPAGSNPGPESEGSGVPPRPEEADETWDSKEDKIHNAENIQPGEQKYEYKSDQ
WKPLNLEEKKRYDREFLLGFQFIFASMQKPEGLPHISDVVLDKANKTPLRPLDPTRLQGI
NCGPDFTPSFANLGRTTLSTRGPPRGGPGGELPRGPAGLGPRRSQQGPRKEPRKIIATVL
MTEDIKLNKAEKAWKPSSKRTAADKDRGEEDADGSKTQDLFRRVRSILNKLTPQMFQQLM
KQVTQLAIDTEERLKGVIDLIFEKAISEPNFSVAYANMCRCLMALKVPTTEKPTVTVNFR
KLLLNRCQKEFEKDKDDDEVFEKKQKEMDEAATAEERGRLKEELEEARDIARRRSLGNIK
FIGELFKLKMLTEAIMHDCVVKLLKNHDEESLECLCRLLTTIGKDLDFEKAKPRMDQYFN
QMEKIIKEKKTSSRIRFMLQDVLDLRGSNWVPRRGDQGPKTIDQIHKEAEMEEHREHIKV
QQLMAKGSDKRRGGPPGPPISRGLPLVDDGGWNTVPISKGSRPIDTSRLTKITKPGSIDS
NNQLFAPGGRLSWGKGSSGGSGAKPSDAASEAARPATSTLNRFSALQQAVPTESTDNRRV
VQRSSLSRERGEKAGDRGDRLERSERGGDRGDRLDRARTPATKRSFSKEVEERSRERPSQ
PEGLRKAASLTEDRDRGRDAVKREAALPPVSPLKAALSEEELEKKSKAIIEEYLHLNDMK
EAVQCVQELASPSLLFIFVRHGVESTLERSAIAREHMGQLLHQLLCAGHLSTAQYYQGLY
EILELAEDMEIDIPHVWLYLAELVTPILQEGGVPMGELFREITKPLRPLGKAASLLLEIL
GLLCKSMGPKKVGTLWREAGLSWKEFLPEGQDIGAFVAEQKVEYTLGEESEAPGQRALPS
EELNRQLEKLLKEGSSNQRVFDWIEANLSEQQIVSNTLVRALMTAVCYSAIIFETPLRVD
VAVLKARAKLLQKYLCDEQKELQALYALQALVVTLEQPPNLLRMFFDALYDEDVVKEDAF
YSWESSKDPAEQQGKGVALKSVTAFFKWLREAEEESDHN
|
|
|
|---|
| BDBM40324 |
|---|
| n/a |
|---|
| Name | BDBM40324 |
|---|
| Synonyms: | (4Z)-2-nitro-4-[(2-thiazolylhydrazo)methylidene]-1-cyclohexa-2,5-dienone | (4Z)-2-nitro-4-[(N'-thiazol-2-ylhydrazino)methylene]cyclohexa-2,5-dien-1-one | (4Z)-2-nitro-4-[[2-(1,3-thiazol-2-yl)hydrazinyl]methylidene]cyclohexa-2,5-dien-1-one | 4-hydroxy-3-nitrobenzaldehyde 1,3-thiazol-2-ylhydrazone | MLS000530638 | SMR000135616 | cid_9552014 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C10H8N4O3S |
|---|
| Mol. Mass. | 264.261 |
|---|
| SMILES | [O-][N+](=O)c1c[c-](C[NH+]=Nc2nccs2)ccc1=O |w:7.6| |
|---|
| Structure | 
|
|---|
Search and Browse
