Reaction Details |
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Target | Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Ligand | BDBM50114 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors |
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IC50 | 400±n/a nM |
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Citation | PubChem, PC Dose Response Confirmation for Mcl-1/Noxa Interaction Inhibitors PubChem Bioassay(2008)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Induced myeloid leukemia cell differentiation protein Mcl-1 |
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Name: | Induced myeloid leukemia cell differentiation protein Mcl-1 |
Synonyms: | BCL2L3 | Bcl-2-like protein 3 | Bcl-2-like protein 3 (Mcl-1) | Bcl-2-related protein EAT/mcl1 | Bcl2-L-3 | Induced myeloid leukemia cell differentiation protein (Mcl-1) | MCL1 | MCL1_HUMAN | Mcl-1 | Myeloid Cell factor-1 (Mcl-1) | Myeloid cell leukemia sequence 1 (BCL2-related) | mcl1/EAT |
Type: | Membrane; Single-pass membrane protein |
Mol. Mass.: | 37332.87 |
Organism: | Homo sapiens (Human) |
Description: | Q07820 |
Residue: | 350 |
Sequence: | MFGLKRNAVIGLNLYCGGAGLGAGSGGATRPGGRLLATEKEASARREIGGGEAGAVIGGS
AGASPPSTLTPDSRRVARPPPIGAEVPDVTATPARLLFFAPTRRAAPLEEMEAPAADAIM
SPEEELDGYEPEPLGKRPAVLPLLELVGESGNNTSTDGSLPSTPPPAEEEEDELYRQSLE
IISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQRNHETAFQGMLRKLDIKNE
DDVKSLSRVMIHVFSDGVTNWGRIVTLISFGAFVAKHLKTINQESCIEPLAESITDVLVR
TKRDWLVKQRGWDGFVEFFHVEDLEGGIRNVLLAFAGVAGVGAGLAYLIR
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BDBM50114 |
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n/a |
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Name | BDBM50114 |
Synonyms: | 4-(1-carbomethoxy-2,2,2-trifluoro-1-hydroxy-ethyl)-5-(dimethylaminomethyleneamino)furan-2-carboxylic acid ethyl ester | 5-(dimethylaminomethylideneamino)-4-(1,1,1-trifluoro-2-hydroxy-3-methoxy-3-oxopropan-2-yl)-2-furancarboxylic acid ethyl ester | MLS000568991 | SMR000150028 | cid_5179585 | ethyl 5-(dimethylaminomethylideneamino)-4-(1,1,1-trifluoro-2-hydroxy-3-methoxy-3-oxopropan-2-yl)furan-2-carboxylate | ethyl 5-(dimethylaminomethylideneamino)-4-[1,1,1-tris(fluoranyl)-3-methoxy-2-oxidanyl-3-oxidanylidene-propan-2-yl]furan-2-carboxylate |
Type | Small organic molecule |
Emp. Form. | C14H17F3N2O6 |
Mol. Mass. | 366.2898 |
SMILES | CCOC(=O)c1cc(c(N=CN(C)C)o1)C(O)(C(=O)OC)C(F)(F)F |w:9.8| |
Structure |
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