| Reaction Details |
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 | Report a problem with these data |
| Target | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Ligand | BDBM43793 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay |
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| EC50 | 4380±n/a nM |
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| Citation |  PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Alkaline phosphatase, tissue-nonspecific isozyme |
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| Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
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| Synonyms: | ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor |
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| Type: | PROTEIN |
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| Mol. Mass.: | 57306.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1448917 |
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| Residue: | 524 |
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| Sequence: | MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
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| BDBM43793 |
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| n/a |
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| Name | BDBM43793 |
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| Synonyms: | MLS-0239358.0001 | N'-[1-(2,4-dimethylphenyl)-4-pyrazolo[3,4-d]pyrimidinyl]-2-furancarbohydrazide | N'-[1-(2,4-dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]-2-furohydrazide | N'-[1-(2,4-dimethylphenyl)pyrazolo[3,4-d]pyrimidin-4-yl]furan-2-carbohydrazide | cid_16194260 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16N6O2 |
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| Mol. Mass. | 348.3586 |
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| SMILES | Cc1ccc(c(C)c1)-n1ncc2c(NNC(=O)c3ccco3)ncnc12 |
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| Structure | 
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