Ki Summary

Reaction Details

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Target

Alkaline phosphatase, tissue-nonspecific isozyme

Ligand

BDBM46434

Substrate/Competitor

n/a

Meas. Tech.

SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay

EC50

740±n/a nM

Citation

PubChem, PC SAR assay for compounds activating TNAP in the presence of 100 mM DEA performed in a luminescence assay PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Alkaline phosphatase, tissue-nonspecific isozyme

Name:

Alkaline phosphatase, tissue-nonspecific isozyme

Synonyms:

ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor

Type:

PROTEIN

Mol. Mass.:

57306.17

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1448917

Residue:

524

Sequence:

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

BDBM46434

n/a

Name

BDBM46434

Synonyms:

1'-(phenylmethyl)-2'-spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indole]one | 1'-(phenylmethyl)spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indole]-2'-one | 1'-benzylspiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indole]-2'-one | 1'-benzylspiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indoline]-2'-one | MLS-0315871.0001 | cid_4879301

Type

Small organic molecule

Emp. Form.

C21H17N3O2

Mol. Mass.

343.3786

SMILES

O=C1N(Cc2ccccc2)c2ccccc2C11NNc2ccccc2O1

Structure