Reaction Details |
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Target | Beta-lactamase |
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Ligand | BDBM52043 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. |
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IC50 | 59640±n/a nM |
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Citation | PubChem, PC Epi-absorbance-based counterscreen for selective VIM-2 inhibitors: dose response biochemical high throughput screening assay to identify inhibitors of IMP-1 metallo-beta-lactamase. PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Beta-lactamase |
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Name: | Beta-lactamase |
Synonyms: | Beta-lactamase | metallo-beta-lactamase IMP-1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 27125.88 |
Organism: | Pseudomonas aeruginosa |
Description: | gi_27368096 |
Residue: | 246 |
Sequence: | MSKLSVFFIFLFCSIATAAESLPDLKIEKLDEGVYVHTSFEEVNGWGVVPKHGLVVLVNA
EAYLIDTPFTAKDTEKLVTWFVERGYKIKGSISSHFHSDSTGGIEWLNSRSIPTYASELT
NELLKKDGKVQATNSFSGVNYWLVKNKIEVFYPGPGHTPDNVVVWLPERKILFGGCFIKP
YGLGNLGDANIEAWPKSAKLLKSKYGKAKLVVPSHSEVGDASLLKLTLEQAVKGLNESKK
PSKPSN
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BDBM52043 |
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n/a |
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Name | BDBM52043 |
Synonyms: | (2S)-1-[2-[(4-butyl-2-keto-8,8-dimethyl-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]proline | (2S)-1-[2-[(4-butyl-8,8-dimethyl-2-oxidanylidene-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]ethanoyl]pyrrolidine-2-carboxylic acid | (2S)-1-[2-[(4-butyl-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-h][1]benzopyran-5-yl)oxy]-1-oxoethyl]-2-pyrrolidinecarboxylic acid | (2S)-1-[2-[(4-butyl-8,8-dimethyl-2-oxo-9,10-dihydropyrano[2,3-h]chromen-5-yl)oxy]acetyl]pyrrolidine-2-carboxylic acid | MLS001158165 | SMR000652389 | cid_16406742 |
Type | Small organic molecule |
Emp. Form. | C25H31NO7 |
Mol. Mass. | 457.5161 |
SMILES | CCCCc1cc(=O)oc2c3CCC(C)(C)Oc3cc(OCC(=O)N3CCC[C@H]3C(O)=O)c12 |
Structure |
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