Ki Summary

Reaction Details

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Target

POsterior Segregation

Ligand

BDBM51283

Substrate/Competitor

n/a

Meas. Tech.

Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA

EC50

4601±n/a nM

Citation

PubChem, PC Fluorescent Polarization Homogeneous Dose Response HTS to Indentify Inhibitors of POS-1 Binding to mex-3-RNA PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

POsterior Segregation

Name:

POsterior Segregation

Synonyms:

POsterior Segregation family member (pos-1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

29838.90

Organism:

Caenorhabditis elegans

Description:

gi_17562800

Residue:

264

Sequence:

MADNDFLSGEAIMVFKKEILDSHSDFTRSLSHQSASPEAYDQENVFSQDFQPFMKQDKET
QNSASQPTSEQSLANRDPCTVPDDLREEMMRQRRKEDAFKTALCDAYKRSQACSYGDQCR
FAHGVHELRLPMNPRGRNHPKYKTVLCDKFSMTGNCKYGTRCQFIHKIVDGNAAKLASGA
HANTSSKSPARNAAAHNHSLFVPQGSTDRSMDLNQSLPIRQSDLVRAFARATRLDVSGYN
STAQLAQYFESQFQRIQQLSSHHH

BDBM51283

n/a

Name

BDBM51283

Synonyms:

(1R,2R,3R,8aS)-6-Acetyl-3-carbamoyl-1-cyano-2-(4-fluoro-phenyl)-1,2,3,8a-tetrahydro-indolizine-1-car boxylic acid methyl ester | (1R,2R,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylic acid methyl ester | MLS001029786 | SMR000427163 | cid_11913734 | methyl (1R,2R,3R,8aS)-3-aminocarbonyl-1-cyano-6-ethanoyl-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylate | methyl (1R,2R,3R,8aS)-6-acetyl-3-carbamoyl-1-cyano-2-(4-fluorophenyl)-3,8a-dihydro-2H-indolizine-1-carboxylate

Type

Small organic molecule

Emp. Form.

C20H18FN3O4

Mol. Mass.

383.373

SMILES

COC(=O)[C@@]1(C#N)[C@@H]2C=CC(=CN2[C@H]([C@@H]1c1ccc(F)cc1)C(N)=O)C(C)=O |c:8,10|

Structure