Ki Summary

Reaction Details

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Target

Tyrosine-protein phosphatase non-receptor type 7

Ligand

BDBM53512

Substrate/Competitor

n/a

Meas. Tech.

HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target

IC50

100±n/a nM

Citation

PubChem, PC HTS Discovery of Chemical Inhibitors of HePTP, a Leukemia Target PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Tyrosine-protein phosphatase non-receptor type 7

Name:

Tyrosine-protein phosphatase non-receptor type 7

Synonyms:

Type:

Protein

Mol. Mass.:

40530.79

Organism:

Homo sapiens (Human)

Description:

P35236

Residue:

360

Sequence:

MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEP
ICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHA
SKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFW
EMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQY
QEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGC
FIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP

BDBM53512

n/a

Name

BDBM53512

Synonyms:

CEFAMANDOLE SODIUM SALT | Cefamandole nafate | MLS000069575 | Mandol | SMR000058843 | cid_23672568 | sodium;(6R,7R)-3-[(1-methyl-1,2,3,4-tetrazol-5-yl)sulfanylmethyl]-8-oxidanylidene-7-[[(2R)-2-oxidanyl-2-phenyl-ethanoyl]amino]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2R)-2-hydroxy-1-oxo-2-phenylethyl]amino]-3-[[(1-methyl-5-tetrazolyl)thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenyl-acetyl]amino]-8-keto-3-[[(1-methyltetrazol-5-yl)thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate | sodium;(6R,7R)-7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-3-[(1-methyltetrazol-5-yl)sulfanylmethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Type

Small organic molecule

Emp. Form.

C18H17N6O5S2

Mol. Mass.

461.495

SMILES

Cn1nnnc1SCC1=C(N2[C@H](SC1)[C@H](NC(=O)[C@H](O)c1ccccc1)C2=O)C([O-])=O |t:9|

Structure