Ki Summary

Reaction Details

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Target

Mannose-6-phosphate isomerase

Ligand

BDBM41075

Substrate/Competitor

n/a

Meas. Tech.

HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay.

IC50

36431±n/a nM

Citation

PubChem, PC HTS identification of compounds inhibiting phosphomannose isomerase (PMI) via a fluorescence intensity assay. PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Mannose-6-phosphate isomerase

Name:

Mannose-6-phosphate isomerase

Synonyms:

MPI | MPI protein | MPI_HUMAN | Mannose-6-phosphate isomerase | PMI1

Type:

PROTEIN

Mol. Mass.:

46651.35

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1448919

Residue:

423

Sequence:

MAAPRVFPLSCAVQQYAWGKMGSNSEVARLLASSDPLAQIAEDKPYAELWMGTHPRGDAK
ILDNRISQKTLSQWIAENQDSLGSKVKDTFNGNLPFLFKVLSVETPLSIQAHPNKELAEK
LHLQAPQHYPDANHKPEMAIALTPFQGLCGFRPVEEIVTFLKKVPEFQFLIGDEAATHLK
QTMSHDSQAVASSLQSCFSHLMKSEKKVVVEQLNLLVKRISQQAAAGNNMEDIFGELLLQ
LHQQYPGDIGCFAIYFLNLLTLKPGEAMFLEANVPHAYLKGDCVECMACSDNTVRAGLTP
KFIDVPTLCEMLSYTPSSSKDRLFLPTRSQEDPYLSIYDPPVPDFTIMKTEVPGSVTEYK
VLALDSASILLMVQGTVIASTPTTQTPIPLQRGGVLFIGANESVSLKLTEPKDLLIFRAC
CLL

BDBM41075

n/a

Name

BDBM41075

Synonyms:

2-(N-(4-ethoxyphenyl)sulfonylanilino)-N-[[5-(4-nitrophenyl)-2-furanyl]methylideneamino]acetamide | 2-(N-(4-ethoxyphenyl)sulfonylanilino)-N-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]acetamide | 2-[(4-ethoxyphenyl)sulfonyl-phenyl-amino]-N-[[5-(4-nitrophenyl)furan-2-yl]methylideneamino]ethanamide | 4-ethoxy-N-(2-{2-[(5-{4-nitrophenyl}-2-furyl)methylene]hydrazino}-2-oxoethyl)-N-phenylbenzenesulfonamide | MLS000539722 | N-[[5-(4-nitrophenyl)-2-furyl]methyleneamino]-2-(N-p-phenetylsulfonylanilino)acetamide | SMR000162037 | cid_1743666

Type

Small organic molecule

Emp. Form.

C27H24N4O7S

Mol. Mass.

548.567

SMILES

CCOc1ccc(cc1)S(=O)(=O)N(CC(=O)N\N=C\c1ccc(o1)-c1ccc(cc1)[N+]([O-])=O)c1ccccc1

Structure