Reaction Details |
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Target | Ras-related protein Rab-7a |
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Ligand | BDBM54557 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype |
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EC50 | 5458±n/a nM |
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Citation | PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Ras-related protein Rab-7a |
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Name: | Ras-related protein Rab-7a |
Synonyms: | GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 23519.50 |
Organism: | Canis lupus familiaris |
Description: | gi_164058 |
Residue: | 207 |
Sequence: | MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQ
IWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPF
VVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEV
ELYNEFPEPIKLDKNDRAKTSAESCSC
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BDBM54557 |
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n/a |
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Name | BDBM54557 |
Synonyms: | 1-[4-(2,5-dimethylphenyl)-1-piperazinyl]-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]-1-propanone | 1-[4-(2,5-dimethylphenyl)piperazin-1-yl]-3-[3-(2-methylphenyl)-1,2,4-oxadiazol-5-yl]propan-1-one | 1-[4-(2,5-dimethylphenyl)piperazino]-3-[3-(o-tolyl)-1,2,4-oxadiazol-5-yl]propan-1-one | KUC103368N | UNM-0000306078 | cid_42596906 |
Type | Small organic molecule |
Emp. Form. | C24H28N4O2 |
Mol. Mass. | 404.5047 |
SMILES | Cc1ccc(C)c(c1)N1CCN(CC1)C(=O)CCc1nc(no1)-c1ccccc1C |
Structure |
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