| Reaction Details |
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 | Report a problem with these data |
| Target | Ras-related protein Rab-7a |
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| Ligand | BDBM54612 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype |
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| EC50 | 30000±n/a nM |
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| Citation |  PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab7 wildtype PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Ras-related protein Rab-7a |
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| Name: | Ras-related protein Rab-7a |
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| Synonyms: | GTP-binding protein (rab7) | RAB7 | RAB7A | RAB7A_CANLF |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 23519.50 |
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| Organism: | Canis lupus familiaris |
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| Description: | gi_164058 |
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| Residue: | 207 |
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| Sequence: | MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQ
IWDTAGQERFQSLGVAFYRGADCCVLVFDVTAPNTFKTLDSWRDEFLIQASPRDPENFPF
VVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQETEV
ELYNEFPEPIKLDKNDRAKTSAESCSC
|
|
|
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| BDBM54612 |
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| n/a |
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| Name | BDBM54612 |
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| Synonyms: | 2-[4-[bis(fluoranyl)methylsulfonyl]phenyl]-5-(4-bromophenyl)-3-phenyl-3,4-dihydropyrazole | 3-(4-bromophenyl)-1-[4-(difluoromethylsulfonyl)phenyl]-5-phenyl-2-pyrazoline | 5-(4-bromophenyl)-2-[4-(difluoromethylsulfonyl)phenyl]-3-phenyl-3,4-dihydropyrazole | UNM-0000305851 | cid_2865099 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H17BrF2N2O2S |
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| Mol. Mass. | 491.348 |
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| SMILES | FC(F)S(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccccc1)c1ccc(Br)cc1 |c:14| |
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| Structure | 
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