| Reaction Details |
|---|
 | Report a problem with these data |
| Target | GTPase KRas [1-37] |
|---|
| Ligand | BDBM54679 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant |
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| EC50 | 30000±n/a nM |
|---|
| Comments | Extracted from aid = 2043 and tid = 2 |
|---|
| Citation |  PubChem, PC Additional SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras activated mutant PubChem Bioassay(2009)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| GTPase KRas [1-37] |
|---|
| Name: | GTPase KRas [1-37] |
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| Synonyms: | ras protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 4034.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_190938 |
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| Residue: | 37 |
|---|
| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
|
|
|
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| BDBM54679 |
|---|
| n/a |
|---|
| Name | BDBM54679 |
|---|
| Synonyms: | (3E)-4-bromanyl-3-(3-oxidanylidene-1H-inden-2-ylidene)-1H-indol-2-one | (3E)-4-bromo-3-(1-ketoindan-2-ylidene)oxindole | (3E)-4-bromo-3-(3-oxo-1H-inden-2-ylidene)-1H-indol-2-one | UNM-0000305765 | cid_25220926 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C17H10BrNO2 |
|---|
| Mol. Mass. | 340.171 |
|---|
| SMILES | Brc1cccc2NC(=O)\C(=C3/Cc4ccccc4C3=O)c12 |
|---|
| Structure | 
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|---|
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