| Reaction Details |
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 | Report a problem with these data |
| Target | Ras-related protein Rab-2A |
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| Ligand | BDBM11639 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype |
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| EC50 | 30000±n/a nM |
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| Comments | Extracted from aid = 2045 and tid = 2 |
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| Citation |  PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Rab2 wildtype PubChem Bioassay(2016)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| Ras-related protein Rab-2A |
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| Name: | Ras-related protein Rab-2A |
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| Synonyms: | RAB2 | RAB2A | RAB2A_CANLF | Ras-related protein Rab-2A. |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 23545.28 |
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| Organism: | Canis lupus familiaris |
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| Description: | gi_46577642 |
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| Residue: | 212 |
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| Sequence: | MAYAYLFKYIIIGDTGVGKSCLLLQFTDKRFQPVHDLTIGVEFGARMITIDGKQIKLQIW
DTAGQESFRSITRSYYRGAAGALLVYDITRRDTFNHLTTWLEDARQHSNSNMVIMLIGNK
SDLESRREVKKEEGEAFAREHGLIFMETSAKTASNVEEAFINTAKEIYEKIQEGVFDINN
EANGIKIGPQHAATNATHAGNQGGQQAGGGCC
|
|
|
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| BDBM11639 |
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| n/a |
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| Name | BDBM11639 |
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| Synonyms: | 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide | CHEMBL118 | CLX | Celebrex | Celecoxib | US10322118, Urea-Based Scaffold Entry 9 | US11478464, Compound Celecoxib | US11786535, Compound Celecoxib | US8741944, Comparative Compound | US9388139, Celecoxib | cid_2662 |
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| Type | Small organic molecule |
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| Emp. Form. | C17H14F3N3O2S |
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| Mol. Mass. | 381.372 |
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| SMILES | Cc1ccc(cc1)-c1cc(nn1-c1ccc(cc1)S(N)(=O)=O)C(F)(F)F |
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| Structure | 
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