Reaction Details |
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Target | GTPase KRas [1-37] |
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Ligand | BDBM54612 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype |
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EC50 | 30000±n/a nM |
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Citation | PubChem, PC Pyrazoline SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay(2009)[AID] |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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GTPase KRas [1-37] |
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Name: | GTPase KRas [1-37] |
Synonyms: | ras protein |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 4034.04 |
Organism: | Homo sapiens (Human) |
Description: | gi_190938 |
Residue: | 37 |
Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
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BDBM54612 |
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n/a |
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Name | BDBM54612 |
Synonyms: | 2-[4-[bis(fluoranyl)methylsulfonyl]phenyl]-5-(4-bromophenyl)-3-phenyl-3,4-dihydropyrazole | 3-(4-bromophenyl)-1-[4-(difluoromethylsulfonyl)phenyl]-5-phenyl-2-pyrazoline | 5-(4-bromophenyl)-2-[4-(difluoromethylsulfonyl)phenyl]-3-phenyl-3,4-dihydropyrazole | UNM-0000305851 | cid_2865099 |
Type | Small organic molecule |
Emp. Form. | C22H17BrF2N2O2S |
Mol. Mass. | 491.348 |
SMILES | FC(F)S(=O)(=O)c1ccc(cc1)N1N=C(CC1c1ccccc1)c1ccc(Br)cc1 |c:14| |
Structure |
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