| Reaction Details |
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 | Report a problem with these data |
| Target | GTPase KRas [1-37] |
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| Ligand | BDBM48386 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype |
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| EC50 | 30000±n/a nM |
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| Citation |  PubChem, PC Oxadiazole SAR compounds tested via Multiplex dose response to identify specific small molecule inhibitors of Ras and Ras-related GTPases specifically Ras wildtype PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| |
| GTPase KRas [1-37] |
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| Name: | GTPase KRas [1-37] |
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| Synonyms: | ras protein |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 4034.04 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_190938 |
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| Residue: | 37 |
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| Sequence: | MTEYKLVVVGAGGVGKSALTIQLIQNHFVDEYDPTIE
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|
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| BDBM48386 |
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| n/a |
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| Name | BDBM48386 |
|---|
| Synonyms: | 1-{3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]propanoyl}-4-[3-(trifluoromethyl)phenyl]piperazine | 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]-1-propanone | 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]propan-1-one | 3-[3-(4-methoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-[4-[3-(trifluoromethyl)phenyl]piperazino]propan-1-one | MLS000091368 | SMR000025927 | cid_3243472 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H23F3N4O3 |
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| Mol. Mass. | 460.4489 |
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| SMILES | COc1ccc(cc1)-c1noc(CCC(=O)N2CCN(CC2)c2cccc(c2)C(F)(F)F)n1 |
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| Structure | 
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