Ki Summary

Reaction Details

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Target

Amyloid-beta A4 precursor protein-binding family A member 1

Ligand

BDBM53174

Substrate/Competitor

n/a

Meas. Tech.

uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay

IC50

1660±n/a nM

Citation

PubChem, PC uHTS Homogeneous Terbium Time-Resolved Fluorescence Resonance Energy Transfer (HTRF) Assay PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Amyloid-beta A4 precursor protein-binding family A member 1

Name:

Amyloid-beta A4 precursor protein-binding family A member 1

Synonyms:

APBA1_RAT | Apba1 | Mint1 | X11 | neuronal munc18-1 binding protein

Type:

Enzyme Catalytic Domain

Mol. Mass.:

92603.32

Organism:

Rattus norvegicus

Description:

gi_2625023

Residue:

839

Sequence:

MNHLEGSAEVEVADEAPGGEVNESVEADLEHPEVEEEQQPSPPPPAGHAPEDHRAHPAPP
PPPPPQEEEEERGECLARSASTESGFHNHTDTAEGDVLAAARDGYEAERAQDADDESAYA
VQYRPEAEEYTEQAEAEHAEAAQRRALPNHLHFHSLEHEEAMNAAYSGYVYTHRLFHRAE
DEPYAEPYADYGGLQEHVYEEIGDAPELEARDGLRLYERERDEAAAYRQEALGARLHHYD
ERSDGESDSPEKEAEFAPYPRMDSYEQEEDIDQIVAEVKQSMSSQSLDKAAEDMPEAEQD
LERAPTPGGGHPDSPGLPAPAGQQQRVVGTPGGSEVGQRYSKEKRDAISLAIKDIKEAIE
EVKTRTIRSPYTPDEPKEPIWVMRQDISPTRDCDDQRPVDGDSPSPGSSSPLGAESSITP
LHPGDPTEASTNKESRKSLASFPTYVEVPGPCDPEDLIDGIIFAANYLGSTQLLSDKTPS
KNVRMMQAQEAVSRIKTAQKLAKSRKKAPEGESQPMTEVDLFISTQRIKVLNADTQEPMM
DHPLRTISYIADIGNIVVLMARRRMPRSNSQENVEASHPSQDAKRQYKMICHVFESEDAQ
LIAQSIGQAFSVAYQEFLRANGINPEDLSQKEYSDLLNTQDMYNDDLIHFSKSENCKDVF
IEKQKGEILGVVIVESGWGSILPTVIIANMMHGGPAEKSGKLNIGDQIMSINGTSLVGLP
LSTCQSIIKGLKNQSRVKLNIVRCPPVTTVLIRRPDLRYQLGFSVQNGIICSLMRGGIAE
RGGVRVGHRIIEINGQSVVATPHEKIVHILSNAVGEIHMKTMPAAMYRLLTAQEQPVYI

BDBM53174

n/a

Name

BDBM53174

Synonyms:

3,6-bis(2-furanyl)-1,2,4,5-tetrazine | 3,6-bis(2-furyl)-1,2,4,5-tetrazine | 3,6-bis(furan-2-yl)-1,2,4,5-tetrazine | MLS001175855 | SMR000589637 | cid_2554659

Type

Small organic molecule

Emp. Form.

C10H6N4O2

Mol. Mass.

214.1802

SMILES

c1coc(c1)-c1nnc(nn1)-c1ccco1

Structure