| Reaction Details |
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 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 3 |
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| Ligand | BDBM54958 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | SAR Compounds tested by Dose Response Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 3 Wildtype. |
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| EC50 | >30000±n/a nM |
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| Citation |  PubChem, PC SAR Compounds tested by Dose Response Screen via Multiplex HTS Assay for Inhibitors of MEK Kinase PB1 Domains, specifically MEK5 binding to MEK Kinase 3 Wildtype. PubChem Bioassay(2009)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Mitogen-activated protein kinase kinase kinase 3 |
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| Name: | Mitogen-activated protein kinase kinase kinase 3 |
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| Synonyms: | M3K3_HUMAN | MAP3K3 | MAPKKK3 | MEKK3 | Mitogen-activated protein kinase kinase kinase 3 | mitogen-activated protein kinase kinase kinase 3 isoform 1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 70916.05 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_774345 |
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| Residue: | 626 |
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| Sequence: | MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAF
SRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILL
LSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVSSQNPGRSSPPPG
YVPERQQHIARQGSYTSINSEGEFIPETSEQCMLDPLSSAENSLSGSCQSLDRSADSPSF
RKSRMSRAQSFPDNRQEYSDRETQLYDKGVKGGTYPRRYHVSVHHKDYSDGRRTFPRIRR
HQGNLFTLVPSSRSLSTNGENMGLAVQYLDPRGRLRSADSENALSVQERNVPTKSPSAPI
NWRRGKLLGQGAFGRVYLCYDVDTGRELASKQVQFDPDSPETSKEVSALECEIQLLKNLQ
HERIVQYYGCLRDRAEKTLTIFMEYMPGGSVKDQLKAYGALTESVTRKYTRQILEGMSYL
HSNMIVHRDIKGANILRDSAGNVKLGDFGASKRLQTICMSGTGMRSVTGTPYWMSPEVIS
GEGYGRKADVWSLGCTVVEMLTEKPPWAEYEAMAAIFKIATQPTNPQLPSHISEHGRDFL
RRIFVEARQRPSAEELLTHHFAQLMY
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| BDBM54958 |
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| n/a |
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| Name | BDBM54958 |
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| Synonyms: | 6-(3-methoxyphenyl)-3-(2-pyridinyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3-methoxyphenyl)-3-(2-pyridyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | 6-(3-methoxyphenyl)-3-pyridin-2-yl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole | VU0221125-3 | cid_662681 |
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| Type | Small organic molecule |
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| Emp. Form. | C15H11N5OS |
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| Mol. Mass. | 309.346 |
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| SMILES | COc1cccc(c1)-c1nn2c(nnc2s1)-c1ccccn1 |
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| Structure | 
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