Ki Summary

Reaction Details

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Target

Neutrophil cytosol factor 1 [S99G]

Ligand

BDBM55413

Substrate/Competitor

n/a

Meas. Tech.

Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)

IC50

3500±n/a nM

Citation

PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Neutrophil cytosol factor 1 [S99G]

Name:

Neutrophil cytosol factor 1 [S99G]

Synonyms:

NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44664.39

Organism:

Homo sapiens (Human)

Description:

gi_115298672

Residue:

390

Sequence:

MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV

BDBM55413

n/a

Name

BDBM55413

Synonyms:

(8E)-2-amino-6-(phenylmethyl)-4-(3-pyridinyl)-8-(3-pyridinylmethylidene)-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile | (8E)-2-amino-6-benzyl-4-(3-pyridyl)-8-(3-pyridylmethylene)-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile | (8E)-2-amino-6-benzyl-4-pyridin-3-yl-8-(pyridin-3-ylmethylidene)-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile | (8E)-2-azanyl-6-(phenylmethyl)-4-pyridin-3-yl-8-(pyridin-3-ylmethylidene)-5,7-dihydro-4H-pyrano[3,2-c]pyridine-3-carbonitrile | MLS000519445 | SMR000129864 | cid_6309183

Type

Small organic molecule

Emp. Form.

C27H23N5O

Mol. Mass.

433.5044

SMILES

N=C1OC2=C(CN(Cc3ccccc3)CC2=Cc2cccnc2)C(C1C#N)c1cccnc1 |w:16.18,t:3|

Structure