Ki Summary

Reaction Details

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Target

Neutrophil cytosol factor 1 [S99G]

Ligand

BDBM39715

Substrate/Competitor

n/a

Meas. Tech.

Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)

IC50

1800±n/a nM

Citation

PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Neutrophil cytosol factor 1 [S99G]

Name:

Neutrophil cytosol factor 1 [S99G]

Synonyms:

NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44664.39

Organism:

Homo sapiens (Human)

Description:

gi_115298672

Residue:

390

Sequence:

MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV

BDBM39715

n/a

Name

BDBM39715

Synonyms:

(4E)-2-(4-fluorophenyl)-4-[(2Z)-2-(1,3,3-trimethyl-2-indolylidene)ethylidene]-5-oxazolone | (4E)-2-(4-fluorophenyl)-4-[(2Z)-2-(1,3,3-trimethylindol-2-ylidene)ethylidene]-1,3-oxazol-5-one | (4E)-2-(4-fluorophenyl)-4-[(2Z)-2-(1,3,3-trimethylindolin-2-ylidene)ethylidene]-2-oxazolin-5-one | MLS000567247 | SMR000153968 | cid_2557934

Type

Small organic molecule

Emp. Form.

C22H19FN2O2

Mol. Mass.

362.3969

SMILES

CN1\C(=C/C=C2/N=C(OC2=O)c2ccc(F)cc2)C(C)(C)c2ccccc12 |c:6|

Structure