Ki Summary

Reaction Details

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Target

Neutrophil cytosol factor 1 [S99G]

Ligand

BDBM55631

Substrate/Competitor

n/a

Meas. Tech.

Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)

IC50

390±n/a nM

Citation

PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Neutrophil cytosol factor 1 [S99G]

Name:

Neutrophil cytosol factor 1 [S99G]

Synonyms:

NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44664.39

Organism:

Homo sapiens (Human)

Description:

gi_115298672

Residue:

390

Sequence:

MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV

BDBM55631

n/a

Name

BDBM55631

Synonyms:

(E)-2-cyano-3-[(3E)-3-[4-(diethylamino)benzylidene]-2-morpholino-cyclopenten-1-yl]-N-(2-fluorophenyl)acrylamide | (E)-2-cyano-3-[(3E)-3-[[4-(diethylamino)phenyl]methylidene]-2-(4-morpholinyl)-1-cyclopentenyl]-N-(2-fluorophenyl)-2-propenamide | (E)-2-cyano-3-[(3E)-3-[[4-(diethylamino)phenyl]methylidene]-2-morpholin-4-yl-cyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide | (E)-2-cyano-3-[(3E)-3-[[4-(diethylamino)phenyl]methylidene]-2-morpholin-4-ylcyclopenten-1-yl]-N-(2-fluorophenyl)prop-2-enamide | MLS000391884 | SMR000260917 | cid_6061423

Type

Small organic molecule

Emp. Form.

C30H33FN4O2

Mol. Mass.

500.607

SMILES

CCN(CC)c1ccc(\C=C2/CCC(\C=C(/C#N)C(=O)Nc3ccccc3F)=C2N2CCOCC2)cc1 |c:28|

Structure