Ki Summary

Reaction Details

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Target

Neutrophil cytosol factor 1 [S99G]

Ligand

BDBM50671

Substrate/Competitor

n/a

Meas. Tech.

Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)

IC50

3760±n/a nM

Citation

PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Neutrophil cytosol factor 1 [S99G]

Name:

Neutrophil cytosol factor 1 [S99G]

Synonyms:

NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44664.39

Organism:

Homo sapiens (Human)

Description:

gi_115298672

Residue:

390

Sequence:

MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV

BDBM50671

n/a

Name

BDBM50671

Synonyms:

4-[(E)-2-cyano-2-(4-keto-5,6,7,8-tetrahydro-3H-benzothiopheno[2,3-d]pyrimidin-2-yl)vinyl]benzoic acid | 4-[(E)-2-cyano-2-(4-oxidanylidene-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)ethenyl]benzoic acid | 4-[(E)-2-cyano-2-(4-oxo-5,6,7,8-tetrahydro-3H-[1]benzothiolo[2,3-d]pyrimidin-2-yl)ethenyl]benzoic acid | MLS000761451 | SMR000371545 | cid_6144007

Type

Small organic molecule

Emp. Form.

C20H15N3O3S

Mol. Mass.

377.416

SMILES

OC(=O)c1ccc(C=C(C#N)c2nc3sc4CCCCc4c3c(=O)[nH]2)cc1 |w:7.6|

Structure