Ki Summary

Reaction Details

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Target

Neutrophil cytosol factor 1 [S99G]

Ligand

BDBM55902

Substrate/Competitor

n/a

Meas. Tech.

Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs)

IC50

50000±n/a nM

Citation

PubChem, PC Dose Response Confirmation for small molecular inhibitors for p47phox, a regulatory protein of NADPH oxidases (Noxs) PubChem Bioassay(2008)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Neutrophil cytosol factor 1 [S99G]

Name:

Neutrophil cytosol factor 1 [S99G]

Synonyms:

NCF1 | NCF1_HUMAN | NOXO2 | SH3PXD1A | neutrophil cytosolic factor 1

Type:

Enzyme Catalytic Domain

Mol. Mass.:

44664.39

Organism:

Homo sapiens (Human)

Description:

gi_115298672

Residue:

390

Sequence:

MGDTFIRHIALLGFEKRFVPSQHYVYMFLVKWQDLSEKVVYRRFTEIYEFHKTLKEMFPI
EAGAINPENRIIPHLPAPKWFDGQRAAENRQGTLTEYCGTLMSLPTKISRCPHLLDFFKV
RPDDLKLPTDNQTKKPETYLMPKDGKSTATDITGPIILQTYRAIANYEKTSGSEMALSTG
DVVEVVEKSESGWWFCQMKAKRGWIPASFLEPLDSPDETEDPEPNYAGEPYVAIKAYTAV
EGDEVSLLEGEAVEVIHKLLDGWWVIRKDDVTGYFPSMYLQKSGQDVSQAQRQIKRGAPP
RRSSIRNAHSIHQRSRKRLSQDAYRRNSVRFLQQRRRQARPGPQSPGSPLEEERQTQRSK
PQPAVPPRPSADLILNRCSESTKRKLASAV

BDBM55902

n/a

Name

BDBM55902

Synonyms:

(5S)-4-[2-(3,4-dichlorophenyl)ethyl]-1-[(1R)-5-[methyl-(4-phenylbenzyl)amino]-1-[[(4-phenylbenzyl)amino]methyl]pentyl]-5-phenyl-piperazine-2,3-quinone | (5S)-4-[2-(3,4-dichlorophenyl)ethyl]-1-[(2R)-6-[methyl-[(4-phenylphenyl)methyl]amino]-1-[(4-phenylphenyl)methylamino]hexan-2-yl]-5-phenyl-piperazine-2,3-dione | (5S)-4-[2-(3,4-dichlorophenyl)ethyl]-1-[(2R)-6-[methyl-[(4-phenylphenyl)methyl]amino]-1-[(4-phenylphenyl)methylamino]hexan-2-yl]-5-phenylpiperazine-2,3-dione | MLS000697902 | SMR000386383 | cid_16745342

Type

Small organic molecule

Emp. Form.

C51H52Cl2N4O2

Mol. Mass.

823.89

SMILES

CN(CCCC[C@H](CNCc1ccc(cc1)-c1ccccc1)N1C[C@@H](N(CCc2ccc(Cl)c(Cl)c2)C(=O)C1=O)c1ccccc1)Cc1ccc(cc1)-c1ccccc1

Structure