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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Cyclin-dependent kinase 2 | ||
| Ligand | BDBM59088 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Inhibition Assay | ||
| IC50 | 165±n/a nM | ||
| Citation |  McInnes, C; Wang, S; Anderson, S; O'Boyle, J; Jackson, W; Kontopidis, G; Meades, C; Mezna, M; Thomas, M; Wood, G; Lane, DP; Fischer, PM Structural determinants of CDK4 inhibition and design of selective ATP competitive inhibitors. Chem Biol11:525-34 (2004) [PubMed] Article | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Cyclin-dependent kinase 2 | |||
| Name: | Cyclin-dependent kinase 2 | ||
| Synonyms: | CDK2 | CDK2-Kinase | CDK2_HUMAN | CDKN2 | Cell division protein kinase 2 | Cyclin-dependent kinase 2 (CDK2) | Protein cereblon/Cyclin-dependent kinase 2 | p33 protein kinase | ||
| Type: | Enzyme Subunit | ||
| Mol. Mass.: | 33938.17 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P24941 | ||
| Residue: | 298 | ||
| Sequence: |
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| BDBM59088 | |||
| n/a | |||
| Name | BDBM59088 | ||
| Synonyms: | PD0183812 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H36N5O2 | ||
| Mol. Mass. | 474.6172 | ||
| SMILES | OCCCC1CC[NH+](CC1)c1ccc(Nc2ncc3ccc(=O)n(C4CC5CCC4C5)c3n2)cc1 |THB:23:24:27.28:30,(.54,6.93,;1.87,7.7,;3.2,6.93,;4.54,7.7,;5.87,6.93,;7.2,7.7,;8.54,6.93,;8.54,5.39,;7.2,4.62,;5.87,5.39,;9.87,4.62,;9.87,3.08,;11.21,2.31,;12.54,3.08,;13.87,2.31,;15.21,3.08,;15.21,4.62,;16.54,5.39,;17.87,4.62,;19.21,5.39,;20.54,4.62,;20.54,3.08,;21.88,2.31,;19.21,2.31,;19.21,.77,;17.67,.77,;18.44,-.56,;18.04,-2.05,;19.58,-2.05,;19.98,-.56,;20.32,.32,;17.87,3.08,;16.54,2.31,;12.54,4.62,;11.21,5.39,)| | ||
| Structure | 
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