Ki Summary

Reaction Details

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Target

Alkaline phosphatase, tissue-nonspecific isozyme

Ligand

BDBM39713

Substrate/Competitor

n/a

Meas. Tech.

uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay

EC50

195±n/a nM

Citation

PubChem, PC uHTS identification of compounds activating TNAP in the absence of phosphate acceptor performed in luminescent assay PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

Alkaline phosphatase, tissue-nonspecific isozyme

Name:

Alkaline phosphatase, tissue-nonspecific isozyme

Synonyms:

ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor

Type:

PROTEIN

Mol. Mass.:

57306.17

Organism:

Homo sapiens (Human)

Description:

ChEMBL_1448917

Residue:

524

Sequence:

MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGD
GMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCG
VKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAH
SADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDE
KARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELN
RNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIG
QAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPG
YKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYV
PHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF

BDBM39713

n/a

Name

BDBM39713

Synonyms:

1'-allylspiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indoline]-2'-one | 1'-prop-2-enyl-2'-spiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indole]one | 1'-prop-2-enylspiro[1,2-dihydro-4,1,2-benzoxadiazine-3,3'-indole]-2'-one | MLS000566659 | SMR000153589 | cid_4879299

Type

Small organic molecule

Emp. Form.

C17H15N3O2

Mol. Mass.

293.3199

SMILES

C=CCN1C(=O)C2(NNc3ccccc3O2)c2ccccc12

Structure