Ki Summary

Reaction Details

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Target

M17 leucyl aminopeptidase

Ligand

BDBM59585

Substrate/Competitor

n/a

Meas. Tech.

Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP)

IC50

1000±n/a nM

Citation

PubChem, PC Inhibitors of Plasmodium falciparum M17- Family Leucine Aminopeptidase (M17LAP) PubChem Bioassay(2009)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

M17 leucyl aminopeptidase

Name:

M17 leucyl aminopeptidase

Synonyms:

leucine aminopeptidase

Type:

Enzyme Catalytic Domain

Mol. Mass.:

67834.32

Organism:

Plasmodium falciparum 3D7

Description:

gi_124809582

Residue:

605

Sequence:

MYFSSLCKFLPISEKEKIYLNIVKKRFCKSNIYYNNNNNNIINYNKRGLKFYPFCNNLKK
NINFVNINNKKGINFHSINKERKMASEVPQVVSLDPTSIPIEYNTPIHDIKVQVYDIKGG
CNVEEGLTIFLVNNPGKENGPVKISSKVNDKNVSEFLKDENMEKFNVKLGTSKHFYMFND
NKNSVAVGYVGCGSVADLSEADMKRVVLSLVTMLHDNKLSKLTVVFEINVDKNLFRFFLE
TLFYEYMTDERFKSTDKNVNMEYIKHLGVYINNADTYKEEVEKARVYYFGTYYASQLIAA
PSNYCNPVSLSNAAVELAQKLNLEYKILGVKELEELKMGAYLSVGKGSMYPNKFIHLTYK
SKGDVKKKIALVGKGITFDSGGYNLKAAPGSMIDLMKFDMSGCAAVLGCAYCVGTLKPEN
VEIHFLSAVCENMVSKNSYRPGDIITASNGKTIEVGNTDAEGRLTLADALVYAEKLGVDY
IVDIATLTGAMLYSLGTSYAGVFGNNEELINKILNSSKTSNEPVWWLPIINEYRATLNSK
YADINNISSSVKASSIVASLFLKEFVQNTAWAHIDIAGVSWNFKARKPKGFGVRLLTEFV
LNDAL

BDBM59585

n/a

Name

BDBM59585

Synonyms:

MLS000073965 | N-(4-Diethylamino-2-methyl-phenyl)-2-[5-(2,3-dimethoxy-phenyl)-tetrazol-2-yl]-acetamide | N-[4-(diethylamino)-2-methyl-phenyl]-2-[5-(2,3-dimethoxyphenyl)-1,2,3,4-tetrazol-2-yl]ethanamide | N-[4-(diethylamino)-2-methyl-phenyl]-2-[5-(2,3-dimethoxyphenyl)tetrazol-2-yl]acetamide | N-[4-(diethylamino)-2-methylphenyl]-2-[5-(2,3-dimethoxyphenyl)-2-tetrazolyl]acetamide | N-[4-(diethylamino)-2-methylphenyl]-2-[5-(2,3-dimethoxyphenyl)tetrazol-2-yl]acetamide | SMR000006803 | cid_648837

Type

Small organic molecule

Emp. Form.

C22H28N6O3

Mol. Mass.

424.4961

SMILES

CCN(CC)c1ccc(NC(=O)Cn2nnc(n2)-c2cccc(OC)c2OC)c(C)c1

Structure