Ki Summary

Reaction Details

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Target

SUMO-activating enzyme subunit 1

Ligand

BDBM29635

Substrate/Competitor

n/a

Meas. Tech.

uHTS HTRF assay for identification of inhibitors of SUMOylation

IC50

3930±n/a nM

Citation

PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID]

More Info.:

Get all data from this article, Solution Info, Assay Method

SUMO-activating enzyme subunit 1

Name:

SUMO-activating enzyme subunit 1

Synonyms:

AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A

Type:

Enzyme Catalytic Domain

Mol. Mass.:

38440.84

Organism:

Homo sapiens (Human)

Description:

gi_17390638

Residue:

346

Sequence:

MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK

BDBM29635

n/a

Name

BDBM29635

Synonyms:

1-(2-furanylmethyl)-2-imino-3-(4-methylphenyl)sulfonyl-5-dipyrido[1,2-d:3',4'-f]pyrimidinone | 1-(2-furfuryl)-2-imino-3-tosyl-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 1-(2-furylmethyl)-2-imino-3-[(4-methylphenyl)sulfonyl]-1,2-dihydro-5H-dipyrido[1,2-a:2',3'-d]pyrimidin-5-one | 1-(furan-2-ylmethyl)-2-imino-3-(4-methylphenyl)sulfonyldipyrido[1,2-d:3',4'-f]pyrimidin-5-one | 2-azanylidene-1-(furan-2-ylmethyl)-3-(4-methylphenyl)sulfonyl-dipyrido[1,2-d:3',4'-f]pyrimidin-5-one | MLS000088152 | SMR000072387 | cid_1083226

Type

Small organic molecule

Emp. Form.

C23H18N4O4S

Mol. Mass.

446.478

SMILES

Cc1ccc(cc1)S(=O)(=O)c1cc2c(nc3ccccn3c2=O)n(Cc2ccco2)c1=N

Structure