| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61158 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 1980±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61158 |
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| n/a |
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| Name | BDBM61158 |
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| Synonyms: | 1-(1-Phenylamino-but-3-enyl)-7-oxa-bicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid dimethyl ester | 4-(1-anilinobut-3-enyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylic acid dimethyl ester;hydrochloride | MLS000527128 | SMR000117602 | cid_9549553 | dimethyl 4-(1-anilinobut-3-enyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate;hydrochloride | dimethyl 4-(1-phenylazanylbut-3-enyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-2,3-dicarboxylate;hydrochloride |
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| Type | Small organic molecule |
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| Emp. Form. | C20H21NO5 |
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| Mol. Mass. | 355.3844 |
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| SMILES | [H]C12OC(C=C1)(C(CC=C)Nc1ccccc1)C(C(=O)OC)=C2C(=O)OC |c:4,23,TLB:23:22:2:4.5,THB:18:17:2:4.5| |
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| Structure | 
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