| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM48667 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 6480±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM48667 |
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| n/a |
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| Name | BDBM48667 |
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| Synonyms: | 3-[5-({3-[2-(3,4-dimethylanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene}methyl)-2-furyl]-2-methylbenzoic acid | 3-[5-[(Z)-[3-[2-(3,4-dimethylanilino)-2-keto-ethyl]-2,4-diketo-thiazolidin-5-ylidene]methyl]-2-furyl]-2-methyl-benzoic acid | 3-[5-[(Z)-[3-[2-(3,4-dimethylanilino)-2-oxoethyl]-2,4-dioxo-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]-2-methylbenzoic acid | 3-[5-[(Z)-[3-[2-(3,4-dimethylanilino)-2-oxoethyl]-2,4-dioxo-5-thiazolidinylidene]methyl]-2-furanyl]-2-methylbenzoic acid | 3-[5-[(Z)-[3-[2-[(3,4-dimethylphenyl)amino]-2-oxidanylidene-ethyl]-2,4-bis(oxidanylidene)-1,3-thiazolidin-5-ylidene]methyl]furan-2-yl]-2-methyl-benzoic acid | MLS000549852 | SMR000113652 | cid_1810805 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H22N2O6S |
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| Mol. Mass. | 490.528 |
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| SMILES | Cc1ccc(NC(=O)CN2C(=O)S\C(=C/c3ccc(o3)-c3cccc(C(O)=O)c3C)C2=O)cc1C |
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| Structure | 
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