| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61164 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 9030±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61164 |
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| n/a |
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| Name | BDBM61164 |
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| Synonyms: | MLS000565971 | N'-[(Z)-(4-chloranyl-2-phenylimino-1,3-thiazol-5-ylidene)methyl]-2-(2-phenylphenoxy)ethanehydrazide | N'-[(Z)-(4-chloro-2-phenylimino-1,3-thiazol-5-ylidene)methyl]-2-(2-phenylphenoxy)acetohydrazide | N'-[(Z)-(4-chloro-2-phenylimino-3-thiazolin-5-ylidene)methyl]-2-(2-phenylphenoxy)acetohydrazide | N'-[(Z)-(4-chloro-2-phenylimino-5-thiazolylidene)methyl]-2-(2-phenylphenoxy)acetohydrazide | SMR000153111 | cid_5971886 |
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| Type | Small organic molecule |
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| Emp. Form. | C24H19ClN4O2S |
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| Mol. Mass. | 462.951 |
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| SMILES | Clc1nc(Nc2ccccc2)sc1C=NNC(=O)COc1ccccc1-c1ccccc1 |w:14.16| |
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| Structure | 
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