| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
|---|
| Ligand | BDBM61167 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
|---|
| IC50 | 4070±n/a nM |
|---|
| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| SUMO-activating enzyme subunit 1 |
|---|
| Name: | SUMO-activating enzyme subunit 1 |
|---|
| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38440.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_17390638 |
|---|
| Residue: | 346 |
|---|
| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
|
|
|
|---|
| BDBM61167 |
|---|
| n/a |
|---|
| Name | BDBM61167 |
|---|
| Synonyms: | 2-(1,3-benzoxazol-2-ylamino)-6-methyl-4-(4-methylphenyl)-N-phenyl-1,4-dihydro-5-pyrimidinecarboxamide | 2-(1,3-benzoxazol-2-ylamino)-6-methyl-4-(4-methylphenyl)-N-phenyl-1,4-dihydropyrimidine-5-carboxamide | 2-(1,3-benzoxazol-2-ylamino)-6-methyl-N-phenyl-4-(p-tolyl)-1,4-dihydropyrimidine-5-carboxamide | MLS000582297 | SMR000200836 | cid_2967155 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H23N5O2 |
|---|
| Mol. Mass. | 437.4931 |
|---|
| SMILES | CC1=NC(Nc2nc3ccccc3o2)=NC(C1C(=O)Nc1ccccc1)c1ccc(C)cc1 |c:15,t:1| |
|---|
| Structure | 
|
|---|
Search and Browse
