| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61189 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 6770±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61189 |
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| n/a |
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| Name | BDBM61189 |
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| Synonyms: | 5-(3-Chloro-phenyl)-furan-2-carboxylic acid (2-oxo-2H-chromen-6-yl)-amide | 5-(3-chlorophenyl)-N-(2-ketochromen-6-yl)-2-furamide | 5-(3-chlorophenyl)-N-(2-oxidanylidenechromen-6-yl)furan-2-carboxamide | 5-(3-chlorophenyl)-N-(2-oxo-1-benzopyran-6-yl)-2-furancarboxamide | 5-(3-chlorophenyl)-N-(2-oxochromen-6-yl)furan-2-carboxamide | MLS000331425 | SMR000220853 | cid_1844438 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H12ClNO4 |
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| Mol. Mass. | 365.767 |
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| SMILES | Clc1cccc(c1)-c1ccc(o1)C(=O)Nc1ccc2oc(=O)ccc2c1 |
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| Structure | 
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