| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61197 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 2310±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61197 |
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| n/a |
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| Name | BDBM61197 |
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| Synonyms: | (2,6-dipyrrolidinopyrimidin-4-yl)-(p-anisylideneamino)amine | 4-methoxybenzaldehyde (2,6-dipyrrolidin-1-ylpyrimidin-4-yl)hydrazone | MLS000720213 | N-[(4-methoxyphenyl)methylideneamino]-2,6-bis(1-pyrrolidinyl)-4-pyrimidinamine | N-[(4-methoxyphenyl)methylideneamino]-2,6-dipyrrolidin-1-yl-pyrimidin-4-amine | N-[(4-methoxyphenyl)methylideneamino]-2,6-dipyrrolidin-1-ylpyrimidin-4-amine | SMR000304742 | cid_2851352 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H26N6O |
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| Mol. Mass. | 366.46 |
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| SMILES | COc1ccc(CN=Nc2cc(nc(n2)N2CCCC2)N2CCCC2)cc1 |w:8.8| |
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| Structure | 
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