| Reaction Details |
|---|
 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
|---|
| Ligand | BDBM52709 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
|---|
| IC50 | 8760±n/a nM |
|---|
| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| SUMO-activating enzyme subunit 1 |
|---|
| Name: | SUMO-activating enzyme subunit 1 |
|---|
| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 38440.84 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | gi_17390638 |
|---|
| Residue: | 346 |
|---|
| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
|
|
|
|---|
| BDBM52709 |
|---|
| n/a |
|---|
| Name | BDBM52709 |
|---|
| Synonyms: | 2-cyano-N'-[(1E)-(2-hydroxy-3-methoxy-5-nitrophenyl)methylene]acetohydrazide | 2-cyano-N'-[(E)-(5-methoxy-3-nitro-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]ethanehydrazide | 2-cyano-N'-[(E)-(5-methoxy-3-nitro-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]acetohydrazide | 2-cyano-N'-[(E)-(5-methoxy-3-nitro-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | 2-cyano-N'-[(E)-(6-keto-5-methoxy-3-nitro-cyclohexa-2,4-dien-1-ylidene)methyl]acetohydrazide | MLS000685641 | SMR000312605 | cid_5884095 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C11H10N4O5 |
|---|
| Mol. Mass. | 278.2209 |
|---|
| SMILES | COc1cc(c[c-](\C=[NH+]\NC(=O)CC#N)c1=O)[N+]([O-])=O |
|---|
| Structure | 
|
|---|
Search and Browse
