| Reaction Details |
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 | Report a problem with these data |
| Target | SUMO-activating enzyme subunit 1 |
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| Ligand | BDBM61205 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | uHTS HTRF assay for identification of inhibitors of SUMOylation |
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| IC50 | 3790±n/a nM |
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| Citation |  PubChem, PC uHTS HTRF assay for identification of inhibitors of SUMOylation PubChem Bioassay(2010)[AID] |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| SUMO-activating enzyme subunit 1 |
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| Name: | SUMO-activating enzyme subunit 1 |
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| Synonyms: | AOS1 | SAE1 | SAE1_HUMAN | SUA1 | SUMO-activating enzyme subunit 1 (SAE1) | SUMO1 activating enzyme subunit 1 | UBLE1A |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 38440.84 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_17390638 |
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| Residue: | 346 |
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| Sequence: | MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVDVKVDTEDIEKKPE
SFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEEKTK
VAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTTSDY
FLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISPDLLPEDFVRYCFSEMA
PVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
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| BDBM61205 |
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| n/a |
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| Name | BDBM61205 |
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| Synonyms: | 1,8-bis(azanyl)-6-methoxy-3-pyrrolidin-1-yl-2,7-naphthyridine-4-carbonitrile;ethanoic acid | 1,8-diamino-6-methoxy-3-pyrrolidino-2,7-naphthyridine-4-carbonitrile | MLS001007001 | SMR000349800 | acetic acid;1,8-diamino-6-methoxy-3-(1-pyrrolidinyl)-2,7-naphthyridine-4-carbonitrile | acetic acid;1,8-diamino-6-methoxy-3-pyrrolidin-1-yl-2,7-naphthyridine-4-carbonitrile | acetic acid;1,8-diamino-6-methoxy-3-pyrrolidino-2,7-naphthyridine-4-carbonitrile | cid_16196095 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H16N6O |
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| Mol. Mass. | 284.3164 |
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| SMILES | COc1cc2c(C#N)c(nc(N)c2c(N)n1)N1CCCC1 |
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| Structure | 
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